Moving to St. Louis?

If you’re considering a move to St. Louis—especially if you’re a medical student preparing for Match Day—the Central West End (CWE) and Clayton’s DeMun neighborhood should be at the top of your list. These vibrant, walkable areas offer a mix of culture, dining, green spaces, and easy access to major medical institutions, making them ideal for students, professionals, and families alike.

Tips to make your Match Day Move Easier

Location & Nearby Employers

One of the biggest draws of the Central West End and DeMun neighborhoods is their proximity to major medical and research institutions. If you’re moving to St. Louis for medical school or residency, you’ll be just minutes away from:

  • Washington University School of Medicine
  • Barnes-Jewish Hospital
  • St. Louis Children’s Hospital
  • Siteman Cancer Center
  • Shriners Hospitals for Children
  • The Cortex Innovation Community (home to tech startups, bioscience companies, and research institutions)

Overview of the Central West End and DeMun

Central West End

The Central West End (CWE), on the other hand, is a lively, urban neighborhood filled with historic charm and modern amenities. Home to many of St. Louis’s best restaurants, cultural institutions, and nightlife spots, CWE offers a more energetic atmosphere with a mix of students, professionals, and longtime residents. With its proximity to major hospitals and research centers, excellent walkability, and vibrant social scene, CWE is a top choice for those seeking an exciting, city-centric lifestyle while still being steps away from work or school.

DeMun

The DeMun neighborhood, located just west of Forest Park in Clayton, offers a quieter, tree-lined residential feel while still providing quick access to these institutions. It’s a short drive or bike ride to Washington University’s medical campus, making it a fantastic option for students and medical professionals looking for a slightly more suburban feel without sacrificing convenience.

The MetroLink light rail connects both neighborhoods to other areas, including Saint Louis University (SLU) and downtown St. Louis.

Housing Options in the Central West End & DeMun

Both neighborhoods offer a range of housing. Costs vary, with luxury units and historic mansions commanding higher prices, while older walk-ups and mid-rise apartments offer more budget-friendly options.

Central West End

  • Luxury Apartments & Condos – Buildings like The Orion, 100 Above the Park, and The Lofts at Euclid offer sleek, modern amenities, concierge services, and proximity to dining and nightlife.
  • Historic Homes & Condos – Many CWE buildings retain their early 20th-century charm, featuring classic brick facades, stained glass, and grand staircases.
  • Single-Family Homes & Townhouses – The CWE has tree-lined streets with historic mansions and beautifully restored homes, though they tend to come with a higher price tag.
  • Student-Friendly Rentals – With many medical students and residents in the area, you’ll find roommate-friendly rental options and mid-range apartments within walking distance of the hospitals.
4228 McPherson has a sought after modern open floorplan in a historic building. This first floor 2 bedroom, 2 bath condo has in-unit laundry and additional storage in basement. In the Central West End and walkable to grocery store, wine bar, and more. List Price: $180,000. Showings start Friday, March 21st.
4355 West Pine: If a luxury home is an option for you, look no further than this gorgeous 4 bed/2.5 bath renovated Central West End home. Features main floor laundry, beautiful sunroom, and office. High-end European kitchen, gorgeous floors and staircase. Views of Cathedral Basilica from 2nd floor sitting room. 4355 West Pine is listed at $879,900 and available to show now.

DeMun Neighborhood

  • Charming Brick Condos – Many DeMun residences feature historic brick architecture, large windows, and hardwood floors, offering a cozy and classic feel.
  • Townhomes & Single-Family Homes – A mix of historic and newer homes, often with small yards and quiet streets—ideal for students or professionals looking for a more residential environment.
  • Proximity to Forest Park – Many homes in DeMun are within walking distance of Forest Park, offering a serene escape from the demands of medical school or work.
6317 Southwood 2W: This lovely 3 bed/2 bath first floor condo is on a quiet street and offers a sunroom and an private outdoor deck. Large dining room perfect for entertaining. Easy walk to coffee shops, restaurants, entertainment and Forest Park. Top rated Clayton School District. This condo is listed at $425,000 and showings start March 19th.

Culture & Community

Both neighborhoods offer a vibrant community with plenty of amenities:

Central West End Highlights

  • Forest Park – One of the largest urban parks in the country, featuring museums, a zoo, walking/biking trails, and The Muny outdoor theater.
  • Literary & Arts Scene – Visit Left Bank Books, the city’s oldest independent bookstore, or explore nearby arts institutions like the Contemporary Art Museum and Pulitzer Arts Foundation.
  • Annual Events – The CWE hosts events like the Halloween street party, Art Walks, and the Cocktail Party festival, bringing locals together.
377 North Boyle Unit A: This first floor 2 bed, 1 bath condo has been beautifully updated and has an open concept kitchen/living/dining area. In unit laundry and deck with Basilica views. 2 assigned parking spaces in secured lot. Showings will start on March 21st.

DeMun Neighborhood Highlights

  • Charming Local Cafés & Shops – The Kaldi’s Coffee flagship location is a favorite study and social spot, while Louie offers some of the best Italian food in the city.
  • Great Walkability – With tree-lined streets and a slower pace, DeMun is perfect for leisurely strolls, studying at outdoor cafés, or enjoying a quiet evening.
  • Forest Park Proximity – Live just steps from jogging trails, golf courses, museums, and lakes for a perfect balance between work and relaxation.

Dining & Nightlife

Both neighborhoods have excellent dining and social spots, whether you want a quiet coffee shop or an upscale dinner experience.

Central West End

Coffee & Study Spots

  • Kaldi’s Coffee – A go-to for med students needing caffeine and Wi-Fi.
  • Northwest Coffee Roasting – A great outdoor patio for studying or unwinding.

Casual Bites & Brunch

  • Bowood by Niche – A picturesque café inside a plant shop.
  • Kingside Diner – Classic diner food with a modern twist.
  • Salt + Smoke – Famous for St. Louis-style BBQ.

Upscale Dining & Nightlife

  • Brasserie by Niche – French-inspired bistro, perfect for special occasions.
  • Yellowbelly – Modern gastropub with a tropical vibe & outstanding craft cocktails.
  • Vicia and Mainlander – Two of St. Louis’s top-rated restaurants.

DeMun Neighborhood

  • Louie – A neighborhood favorite for upscale Italian fare.
  • Kaldi’s Coffee – The flagship location of this beloved St. Louis coffee shop.
  • Sasha’s Wine Bar – A comfortable hangout offering cheese plates and snacks + a rooftop deck.

Why Medical Students & Residents Love CWE & DeMun

  • Walkability & Public Transit – No car needed! Most places are within walking or biking distance, and the MetroLink connects you to other parts of St. Louis.
  • Supportive Medical Community – With so many students and professionals in the area, you’ll find study groups, networking opportunities, and social events geared toward med students.
  • Engaging Atmosphere – A mix of young professionals, families, and long-time residents makes for a welcoming neighborhood with plenty to do.
  • Quick Access to Forest Park – Need a break from studying? Jog, bike, or kayak in one of the best urban parks in the country.

Is CWE or DeMun Right for You?

If you’re moving to St. Louis for medical school, residency, or a new job, both the Central West End and DeMun offer the perfect blend of convenience, culture, and community. Whether you’re looking for a quiet condont to focus on your studies or a vibrant social scene to unwind after long shifts, these neighborhoods have something for everyone.

Thinking about making the move? Schedule a visit and explore these neighborhoods firsthand—you might just find your new home in the heart of St. Louis.